Neural Signal Pathways: Human-to-Human Control
  • Neuroengineering
  • Human
  • Grade 6+

Neuroprosthetics: Exploring Human-to-Human Control

Ever wondered how it feels to control—or be controlled by—someone else? In this lab you’ll dive into the world of neural communication and motor control with our Human-Human Interface experiment.

About the Experiment

What Will You Learn?

What Will You Learn?

  • How the brain sends electrical signals to muscles to control movement.
  • How to measure and influence neural communication using functional electrical stimulation.
  • The basics of neuroprosthetics and their applications in medicine and technology.
Background

Background

Moving lets us explore the world—walking, dancing, or even controlling a robotic limb. Neurons in the motor cortex fire, signals travel down the spinal cord, and muscles contract. By linking two participants, you’ll experience how those signals can “borrow” another person’s muscles, revealing the power of functional electrical stimulation and the promise of neuroprosthetics.

Experiment

  1. Human-Human Interface Experiment

    Human-Human Interface Experiment

    Materials:

    • Human-Human Interface (HHI) device
    • EMG electrode cable (orange)
    • FES electrode cable (black)
    • Patch electrodes (Controller × 3)
    • Square stimulation electrodes (Minion × 2)

    Setup: Two volunteers choose roles: Controller (sends the signal) and Minion (receives stimulation).

  2. Safety First

    Both volunteers must understand the procedure and agree to take part. The Minion must not take part with a pacemaker or other implanted electronic device, metal implants, epilepsy, a heart condition, or pregnancy. Turn the HHI off before attaching, moving or removing stimulation electrodes; start at the lowest intensity and raise it slowly; stop at once if it hurts or either volunteer asks. Keep both stimulation electrodes on one forearm—never across the chest, throat, neck or head.

  3. Controller Setup

    Controller Setup

    Place two EMG patch electrodes on the forearm flexor muscle and a ground patch on the back of the hand. Clip the red leads to the muscle patches and the black lead to ground. Plug the orange cable into the HHI and turn it on. Ask the Controller to flex; all LEDs should light with a strong squeeze. If needed, use the button on the back of the HHI to change how strong a flex must be to trigger it.

  4. Minion Setup

    Minion Setup

    Turn off the HHI. Place the two square stimulation electrodes over the ulnar nerve on the inner (pinky) side of the forearm, just below the elbow (adjust as needed). Connect the black FES cable to the HHI’s Minion port. When ready, power the device back on.

  5. Take Control!

    Take Control!

    Power on the HHI with the intensity set low. The Controller flexes to light the red LED (threshold). The Minion keeps their forearm relaxed at 90° elbow flexion. Gradually turn the intensity knob until the Minion’s hand twitches—this is the threshold. If the Minion is comfortable, increase intensity to evoke a stronger motion. If stimulation is felt but movement is absent, adjust electrode placement.

Results & Analysis

Results & Analysis

Describe the sensations as Controller and as Minion. Measure reaction threshold (LED level vs. intensity dial) and note latency between flex and Minion movement. Discuss how functional electrical stimulation can bridge damaged neural pathways and how signal strength maps to muscle activation.

Draw the signal pathway from the Controller’s motor cortex to the Minion’s hand: motor cortex, spinal cord, the Controller’s forearm flexor muscle, the HHI, the Minion’s ulnar nerve and hand muscles. Label where you recorded the EMG and where the device takes over from the nervous system.

Design Challenge

  1. The Gentlest Reliable Grip

    Engineers who build neuroprosthetics face a real trade-off: enough stimulation to move a hand every single time, but never more than the person wearing it finds comfortable. Can your team find the sweet spot?

    1. Write down your criteria and rank them: the Minion’s hand moves on 5 of 5 flexes, the Minion stays comfortable, and the movement starts quickly. The Minion can call stop at any time.
    2. Try at least three placements of the stimulation electrodes on the Minion’s forearm (both electrodes always on the same forearm, with the HHI off while you move them). For each, note the intensity-dial setting at threshold and how many of 5 flexes moved the hand.
    3. Compare your designs in a table, combine the best features into one final setup, and test it again.
    4. Explain your trade-offs: what did you give up to gain reliability or comfort?
    5. Judge your final setup for a real person who would wear it to grip: what would it cost, is it safe to wear every day, and who could or could not use it?

NGSS alignment

Performance expectations

  • MS-LS1-3 Use argument supported by evidence for how the body is a system of interacting subsystems composed of groups of cells.

    One person's nervous system drives another person's muscles: nerve and muscle subsystems working together.

  • HS-LS1-2 Develop and use a model to illustrate the hierarchical organization of interacting systems that provide specific functions within multicellular organisms.

    Draw the pathway from the Controller's motor cortex to the Minion's hand: brain, spinal cord, nerve and muscle working as one system across two bodies.

  • MS-ETS1-2 Evaluate competing design solutions using a systematic process to determine how well they meet the criteria and constraints of the problem.

    Score at least three electrode placements against ranked criteria in one table (design challenge).

  • MS-ETS1-3 Analyze data from tests to determine similarities and differences among several design solutions to identify the best characteristics of each that can be combined into a new solution to better meet the criteria for success.

    Test at least three electrode placements, compare their data in a table and combine the best features into a final setup (design challenge).

  • HS-ETS1-3 Evaluate a solution to a complex real-world problem based on prioritized criteria and trade-offs that account for a range of constraints, including cost, safety, reliability, and aesthetics, as well as possible social, cultural, and environmental impacts.

    Rank reliability, comfort and speed, explain the trade-offs, and judge the final setup for a real user: cost, everyday safety, who could use it (design challenge).

Science and engineering practices

  • 1 Asking Questions and Defining Problems

    Define the problem: write and rank criteria before testing (design challenge).

  • 2 Developing and Using Models

    Draw the signal pathway from the Controller's motor cortex to the Minion's hand and mark where the device takes over.

  • 3 Planning and Carrying Out Investigations

    Set the Controller's EMG threshold and find the intensity at which the Minion's hand moves.

  • 4 Analyzing and Interpreting Data

    Compare LED level with the intensity dial and note the delay between flex and movement.

  • 6 Constructing Explanations and Designing Solutions

    Design a final setup from the test data and explain it (design challenge).

Crosscutting concepts

  • Cause and Effect

    The Controller's flex causes the Minion's hand to move.

  • Systems and System Models

    Two people and a device form one control loop.

  • Influence of Science, Engineering, and Technology on Society and the Natural World Engineering connection

    Functional electrical stimulation can bridge damaged neural pathways.

Disciplinary core ideas

  • LS1.D Information Processing

    Motor commands are electrical signals carried by nerves.

  • LS1.A Structure and Function

    Nerves and muscles are specialized structures that work together.

  • ETS1.B Developing Possible Solutions

    Test several solutions and weigh comfort against reliability.

  • ETS1.C Optimizing the Design Solution

    Use test results to pick and combine the best design.

Backyard Brains mapping using the book's method. Not in the book. Engineering claims rest on the design challenge on this page (Greg, 2026-10-06; real-user judgment step added 2026-10-08), modelled on the SpikerBot curriculum.